Which SSRI requires dosing at bedtime (QHS)?

Luvox, the correct choice, is an SSRI (selective serotonin reuptake inhibitor) that is often recommended to be taken at bedtime due to its sedative properties. This characteristic can help minimize potential side effects such as insomnia, which some patients may experience when taking SSRIs. Dosing at nighttime allows patients to benefit from the calming effects while avoiding disturbances in their sleep patterns during the day.

In contrast, the other SSRIs listed may not specifically require bedtime dosing. For example, Citalopram and Lexapro are commonly taken in the morning, as they do not typically cause sedation and are less likely to disrupt daytime functioning. Zoloft is similarly dosed based on individual response and preference but is also not primarily associated with bedtime administration for efficacy or side effect management. Therefore, Luvox stands out as the SSRI that is particularly suited for evening dosing due to its unique pharmacological profile.