Which side effect is NOT associated with methotrexate?

Methotrexate is a chemotherapy agent commonly used to treat various conditions, including cancer and autoimmune diseases. It is associated with a number of potential side effects due to its effects on rapidly dividing cells.

Hepatotoxicity is a well-known side effect of methotrexate, resulting from its impact on liver function and the accumulation of the drug in hepatic tissues, potentially leading to liver damage over time. Mucositis, which refers to the inflammation and ulceration of the mucous membranes, is another common complication as methotrexate can damage rapidly dividing epithelial cells in the gastrointestinal tract.

Pulmonary toxicity is also recognized as a serious side effect of methotrexate, where patients may develop pneumonitis or other lung issues related to the medication. This risk underscores the need for monitoring lung function in patients receiving methotrexate therapy.

In contrast, hematuria—the presence of blood in the urine—is not typically associated with methotrexate treatment. While hematuria can occur with other medications or conditions, it is not a common adverse effect of methotrexate. Therefore, identifying hematuria as not being associated with methotrexate is accurate based on the established side effect profile of the drug.