Which side effect is associated with Stavudine (d4T)?

Stavudine (d4T) is an antiretroviral medication used in the treatment of HIV/AIDS, and it is specifically known for its association with pancreatitis. This side effect arises because stavudine can induce toxic effects on pancreatic cells, leading to inflammation and irritation. Symptoms of pancreatitis can include abdominal pain, nausea, vomiting, and elevated levels of pancreatic enzymes in the blood.

In contrast, while osteoporosis is a concern with long-term use of some antiretrovirals, it is not directly linked to stavudine itself. Nephrotoxicity is more commonly associated with other medications used to treat HIV. Rash may occur with various antiretroviral agents but is not primarily attributed to stavudine. Therefore, pancreatitis is the specific and notable side effect that sets stavudine apart from other medications in its class. Understanding this can help healthcare providers monitor patients for specific complications related to their antiretroviral therapy.