Which side effect is associated with Sulfonylureas?

Sulfonylureas, a class of oral medications used to treat type 2 diabetes, are known to stimulate the pancreas to release insulin. One notable side effect associated with their use is weight gain. This occurs because sulfonylureas can increase insulin levels, which may lead to increased appetite and potentially promote fat storage, resulting in weight gain in some patients.

Understanding the other choices provides clarity on why they are not the correct answer. Diarrhea can occur with various medications, especially those affecting the gastrointestinal tract, but it is not directly linked to sulfonylureas. A metallic taste is usually associated with other classes of medications, particularly certain antibiotics or medications like metformin. Lastly, lactic acidosis is primarily associated with metformin, another diabetes medication, rather than sulfonylureas.

Therefore, weight gain is closely connected with the mechanism of sulfonylureas and is recognized as a common side effect of their use in diabetic therapy.