Which serotonin receptor is primarily linked to depression?

The serotonin receptor primarily linked to depression is the 5HT1 receptor. This receptor plays a significant role in affecting mood and emotional regulation. Research has shown that the 5HT1 receptor is involved in the mechanism of action of many antidepressant medications, particularly selective serotonin reuptake inhibitors (SSRIs), which increase serotonin levels in the brain.

Activation of 5HT1 receptors has been linked to antidepressant effects, as they help to modulate the release of serotonin and can influence neurogenesis, particularly in the hippocampus, an area of the brain associated with mood and stress responses. Additionally, dysregulation of serotonin signaling through the 5HT1 receptor has been implicated in the pathophysiology of depression.

In contrast, the other receptors mentioned, such as 5HT2, 5HT3, and 5HT4, may have roles in other psychological conditions or physiological processes but are not directly linked to the depressive symptomatology in the same manner as 5HT1. Thus, the connection between 5HT1 receptors and their role in mood regulation supports their primary association with depression.