Which organism is commonly associated with cystic fibrosis infections?

Pseudomonas aeruginosa is the organism most commonly associated with infections in patients with cystic fibrosis (CF). This is primarily due to the thick, sticky mucus present in the lungs of CF patients, which provides a nutrient-rich environment for the bacteria to thrive. Pseudomonas has a unique ability to form biofilms, making it particularly difficult to eradicate and contributing to the chronic lung infections that characterize CF.

The presence of Pseudomonas in the respiratory tract often leads to a decline in lung function over time and can result in increased morbidity in patients with cystic fibrosis. Treatment typically involves aggressive antibiotic therapy, but resistance to antibiotics can develop, complicating the management of infections caused by this organism.

Although Staphylococcus, Escherichia coli, and Streptococcus can also cause infections, they are not as strongly linked with the chronic pulmonary exacerbations seen in cystic fibrosis patients as Pseudomonas is. The unique pathogenic mechanisms and resistance profiles of Pseudomonas make it the primary concern in the context of cystic fibrosis.