Which of the following treatments aims to control phosphate levels?

Sevelamer is a medication specifically designed to control phosphate levels in patients, particularly those with chronic kidney disease (CKD) who may develop hyperphosphatemia. This condition occurs when there is an accumulation of phosphate in the blood due to the kidneys' inability to excrete it adequately.

Sevelamer works as a phosphate binder; it binds to dietary phosphate in the gastrointestinal tract, preventing its absorption into the bloodstream. This action helps lower serum phosphate levels, which is crucial in managing patients with renal impairment, as elevated phosphate can lead to bone disease and cardiovascular complications.

While hydrochlorothiazide, lisinopril, and simvastatin serve various purposes – such as reducing blood pressure, managing heart conditions, or lowering cholesterol levels – none of them specifically target phosphate control like sevelamer does. Therefore, sevelamer is the treatment of choice for controlling phosphate levels in relevant patient populations.