Which of the following thiazide diuretics is more potent than hydrochlorothiazide?

Chlorthalidone is considered more potent than hydrochlorothiazide due to its longer duration of action and stronger diuretic effect at equivalent doses. Thiazide diuretics work by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron, leading to an increased excretion of sodium and water. Chlorthalidone has a more sustained impact on sodium excretion and blood pressure control compared to hydrochlorothiazide, making it particularly beneficial in treating conditions like hypertension and edema.

Its potency means that it can lead to more significant diuresis and a greater reduction in blood pressure, often at lower doses than those required for hydrochlorothiazide to achieve similar effects. This characteristic contributes to its common use as first-line therapy in managing hypertension, especially in patients who may require stronger or longer-lasting diuretic therapy.

In contrast, the other diuretics listed, while they have their unique properties and indications, do not exhibit a higher potency in comparison to hydrochlorothiazide. Metolazone is effective in specific situations, especially in combination with loop diuretics, but it is not generally classified as more potent than hydrochlorothiazide. Indapamide is also effective but acts differently