Which of the following side effects can result from TCA medications related to heart function?

QTc prolongation is a notable side effect associated with tricyclic antidepressant (TCA) medications. This phenomenon occurs when the time taken for the heart's electrical system to reset after each heartbeat is extended, which can lead to serious cardiac complications, including life-threatening arrhythmias. TCAs can interfere with the heart’s conduction system, causing disturbances that result in a prolonged QT interval as shown on an ECG (electrocardiogram). This is particularly important for clinicians to monitor, especially in patients with existing cardiovascular issues or those taking other medications that might also prolong the QT interval.

Being aware of QTc prolongation is crucial due to its potential to lead to torsades de pointes, a dangerous form of ventricular tachycardia, and since TCAs can have cumulative effects with other substances that affect cardiac function, careful monitoring and management are essential in patients treated with these medications.