Which of the following promotes anticoagulation therapy according to the CHA2DS2-VASc system for females?

The CHA2DS2-VASc scoring system is essential for assessing the risk of stroke in patients with atrial fibrillation, particularly in determining the necessity for anticoagulation therapy. In women, a score of 2 or more indicates a significantly increased risk of thromboembolic events, warranting the initiation of anticoagulation therapy to reduce the likelihood of stroke.

The components of the CHA2DS2-VASc score specifically identify various risk factors: Congestive heart failure, Hypertension, Age ≥ 75 years, Diabetes mellitus, Prior stroke or TIA, Vascular disease, Age 65-74 years, and Sex category (female). For women, being assigned an additional point solely based on gender adds to the overall score, making the threshold for anticoagulation treatment a score of 2 or more.

As a result, the recommendation to initiate anticoagulation therapy aligns with a score of 2 or more in females, as this score reflects a clinically significant risk that justifies the preventive treatment approach. Thus, the basis for promoting anticoagulation therapy according to the CHA2DS2-VASc system specifically for females is correctly noted with a score of 2 or more.