Which of the following medications is recommended to be administered under supervision due to its potential side effects?

Spravato is a medication that is specifically indicated for treatment-resistant depression and must be administered under the supervision of a healthcare professional due to its potential side effects and the way it acts in the brain. This medication, which is a nasal spray form of esketamine, can lead to dissociative effects and sedation, thus requiring monitoring during and after administration. Patients need to be observed for at least two hours post-administration to ensure their safety, as there is a risk of increased blood pressure and other adverse effects. This careful oversight is crucial in managing the risks associated with its use.

In contrast, while medications like Abilify, St. John's wort, and SAMe have their own sets of potential side effects and interactions, they typically do not require the same level of supervision during administration as Spravato. Abilify can be managed in various settings, and St. John's wort and SAMe are often used as supplements without the stringent monitoring necessary for Spravato. Thus, the requirement for administration under supervision highlights the unique profile of Spravato in terms of safety and efficacy management.