Which of the following is a key instruction when administering ciprofloxacin suspension?

When administering ciprofloxacin suspension, a critical instruction is to shake the bottle before use. This step is essential because ciprofloxacin suspension may contain particles that settle at the bottom over time. Shaking the bottle ensures that the medication is evenly distributed throughout the liquid, providing the correct dosage and efficacy when it is administered.

For other options, administering through a feeding tube is not a standard recommendation for all patients and may depend on individual circumstances, including the patient's condition and the prescribing physician's directions. Refrigerating the suspension is generally unnecessary and may alter the formulation. Mixing it with water is not advised since doing so could dilute the medication and affect its absorption and therapeutic effect. Always following the guideline to shake the suspension ensures patients receive the intended dosage and benefit from the treatment.