Which of the following is the combination in Diovan HCT?

Diovan HCT is a medication that combines two active ingredients: valsartan, which is an angiotensin receptor blocker (ARB) used primarily for the treatment of high blood pressure and heart failure, and hydrochlorothiazide (HCTZ), a thiazide diuretic that helps to lower blood pressure by helping the body eliminate excess fluids and sodium. This combination enhances the antihypertensive effects due to the synergistic mechanism of action—valsartan works on the vascular system while HCTZ reduces fluid volume.

Choosing the correct components is critical, as different combinations serve different therapeutic purposes. The pairing of valsartan with hydrochlorothiazide in Diovan HCT specifically addresses both the vascular resistance and fluid overload that can contribute to high blood pressure. This dual action allows for improved blood pressure control while potentially reducing the risk of side effects from higher doses of either component taken alone.