Which of the following is NOT an NNRTI?

Dolutegravir is not classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI); instead, it belongs to a different category of antiretroviral drugs known as integrase strand transfer inhibitors (INSTIs). NNRTIs are primarily used in the treatment of HIV and work by binding to and inhibiting the reverse transcriptase enzyme, which is crucial for the HIV life cycle.

Efavirenz, Neviripine, and Etravirine are all examples of NNRTIs, as they specifically target and inhibit the reverse transcriptase, thereby preventing the conversion of HIV RNA into DNA, which is a critical step for viral replication. By knowing the classification of these medications, it becomes clear why Dolutegravir stands apart as it employs a distinct mechanism by inhibiting the integrase enzyme, emphasizing the importance of understanding different classes of antiretroviral drugs within the context of HIV treatment.