Which of the following is an over-the-counter medication that can be used for depression?

SAMe, or S-adenosylmethionine, is considered an over-the-counter supplement that has been linked to potential benefits in treating depression. It is a naturally occurring compound in the body that contributes to the synthesis of neurotransmitters such as serotonin, which plays a crucial role in mood regulation. Research indicates that SAMe may have a similar efficacy to prescription antidepressants for some individuals, making it a popular choice for those seeking alternative treatment options outside of standard pharmacological approaches.

In contrast, the other options are prescription medications that require a doctor's authorization and supervision. Fluoxetine, sertraline, and citalopram are all selective serotonin reuptake inhibitors (SSRIs), prescribed for the treatment of depression and anxiety disorders. These medications often come with accompanying guidelines, dosage adjustments, and potential side effects that must be managed by a healthcare provider. This distinction is critical in understanding why SAMe is categorized differently compared to the other three options.