Which of the following is a side effect of Amphotericin B?

Amphotericin B is an antifungal medication known for its effectiveness in treating serious fungal infections, but it has a range of side effects due to its mode of action and effects on the body. Shaking and chills, often referred to as "infusion-related reactions," are common side effects experienced by patients when receiving Amphotericin B. These reactions may occur during or shortly after the infusion and are typically related to cytokine release triggered by the drug, resulting in a flu-like syndrome characterized by fever, chills, and shaking.

While hypertension, alopecia, and mild rash can occur with various medications, they are not commonly associated with Amphotericin B. Infusion-related reactions like shaking and chills are significant enough that patients are often premedicated with antipyretics or antihistamines to mitigate these symptoms during treatment. Understanding this typical reaction is crucial for healthcare professionals as they prepare patients for potential side effects during and after the administration of Amphotericin B therapy.