Which of the following is a primary concern when managing digoxin toxicity?

When managing digoxin toxicity, one of the primary concerns is correcting hypokalemia. Digoxin works by inhibiting the sodium-potassium ATPase pump, which can be significantly influenced by potassium levels in the body. Low potassium levels, or hypokalemia, can enhance the effects of digoxin and increase the risk of toxicity because the heart's sensitivity to digoxin increases when potassium is low. This can lead to dangerous arrhythmias and increase the overall risk of serious cardiac outcomes.

In cases of digoxin toxicity, it's crucial to monitor and address potassium levels promptly. Administering potassium supplementation may be necessary to restore balance and minimize complications associated with toxicity. Thus, correcting hypokalemia directly addresses a key factor that can exacerbate the effects of digoxin, making it a critical focus in the management of digoxin toxicity.

By recognizing and treating hypokalemia, healthcare providers can significantly reduce the likelihood of drug-related complications in patients experiencing digoxin toxicity.