Which of the following is a non-calcium containing phosphate binder?

The chosen answer, Renagel, is indeed a non-calcium containing phosphate binder. Renagel, generically known as sevelamer hydrochloride, is often used in patients with chronic kidney disease to manage hyperphosphatemia (high phosphate levels). It works by binding phosphate in the gastrointestinal tract, preventing its absorption into the bloodstream, thus lowering serum phosphate levels without adding additional calcium. This is particularly beneficial for patients who may have underlying issues with calcium levels or who are receiving calcium-rich treatments.

In contrast, aluminum hydroxide and calcium carbonate are both phosphate binders that do contain calcium. Aluminum hydroxide binds phosphates in the gut but presents concerns regarding aluminum toxicity with long-term use. Calcium carbonate not only acts as a binder but also contributes additional calcium to the body's levels, which could lead to hypercalcemia if not monitored carefully. Sodium phosphate, while it is a salt that contains phosphate, is not typically used as a phosphate binder in this context. Therefore, Renagel is the appropriate choice for a non-calcium containing phosphate binder.