Which of the following HIV medications should be taken on an empty stomach?

Videx (Didanosine) is the correct choice for an HIV medication that should be taken on an empty stomach. The reason for this is largely related to its absorption characteristics. When taken with food, especially high-fat meals, the bioavailability of Didanosine decreases, which can lead to less effective treatment outcomes. Taking the medication on an empty stomach ensures that it is absorbed more efficiently into the bloodstream, allowing it to work effectively against the virus.

In contrast, other medications on the list may be taken with or without food. For instance, Emtricitabine, Lopinavir/Ritonavir, and Zidovudine do not have specific requirements regarding food intake affecting their absorption in a way that is comparable to Didanosine. Therefore, while they may have their own guidelines for optimal administration, the distinct requirement for Didanosine highlights why it is crucial for patients to understand the best practices for their specific HIV medications.