Which of the following drugs is associated with causing lupus-like syndrome?

Chlorpromazine is recognized as a drug that can induce a lupus-like syndrome, a condition characterized by symptoms resembling systemic lupus erythematosus (SLE). This reaction is primarily attributed to its pharmacological properties and the way it interacts with the immune system, leading to autoimmune responses. The syndrome may present with symptoms such as joint pain, fever, and serositis, paralleling those of SLE, but it is typically reversible upon discontinuation of the drug.

In contrast, ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for pain relief and inflammation, and while it may cause various side effects, it is not linked to lupus-like syndrome. Acetaminophen, widely used as an analgesic and antipyretic, also does not have associations with causing lupus-like symptoms. Amoxicillin, an antibiotic, is associated with various hypersensitivity reactions but not specifically linked to lupus-like syndrome either. Therefore, chlorpromazine stands out as a notable agent known for its potential to elicit this autoimmune-like condition.