Which of the following drugs can potentially increase INR when taken with warfarin?

When considering the potential interactions of various medications with warfarin, it's essential to understand that certain drugs can influence the anticoagulant effects of warfarin, leading to an increased International Normalized Ratio (INR). An elevated INR indicates a higher risk of bleeding.

Trilpicx, which contains drugs that can affect liver enzymes, may enhance the metabolism of warfarin. Lovaza and Vascepa, both omega-3 fatty acids, have been shown to interact with the coagulation pathway and can potentially increase INR levels by impacting platelet aggregation and altering the metabolism of warfarin.

The mechanism behind these interactions typically involves either direct effects on clotting factors or the inhibition of enzymes responsible for warfarin metabolism. Therefore, any of these drugs can have the potential to raise INR, making it vital for healthcare providers to monitor patients closely for signs of bleeding or changes in clotting status when any of these medications are prescribed alongside warfarin.

As a result, recognizing that all of these drugs can increase INR emphasizes the importance of vigilance in anticoagulation management when introducing any new medications to a patient's regimen.