Which of the following drugs is chemically similar and known to have antidepressant effects?

Amitriptyline is chemically similar to other tricyclic antidepressants and is widely recognized for its antidepressant effects. It works primarily by inhibiting the reuptake of norepinephrine and serotonin in the brain, which increases the levels of these neurotransmitters and thereby helps improve mood and alleviate symptoms of depression. Its structure, characterized by a three-ring configuration, is a hallmark of tricyclic antidepressants.

Other choices, while they may have unique uses or effects, do not align with the same class of compounds or the specific profile of antidepressant activity as amitriptyline does. Selegiline and rasagiline are both monoamine oxidase inhibitors (MAOIs) but are primarily used in the treatment of Parkinson's disease and have distinct mechanisms of action compared to traditional antidepressants. Linezolid, on the other hand, is an antibiotic and does not possess antidepressant properties. Thus, the distinctive medication profile of amitriptyline makes it the most pertinent choice related to antidepressant effects in this context.