Which of the following correctly describes how to administer amoxicillin?

Administering amoxicillin with food is recommended because it can help to enhance absorption and reduce the likelihood of gastrointestinal upset, which is a common side effect of many antibiotics. While amoxicillin can be taken either with or without food, taking it with food can often make it more tolerable for patients, especially for those who may experience nausea or other digestive issues.

Regarding the other options, taking it on an empty stomach for better efficacy or only in a hospital setting could mislead patients about the proper usage of this medication, as amoxicillin can generally be taken at home as prescribed by a healthcare provider. The use of water is also appropriate for swallowing the medication, but it does not necessarily enhance the absorption of the drug as taking it with food may.