Which of the following conditions warrants discontinuation of Aspirin use?

Discontinuation of Aspirin use is primarily warranted in cases of gastrointestinal bleeding. Aspirin is known to increase the risk of bleeding, particularly in the gastrointestinal tract, due to its role as an antiplatelet medication. This effect can lead to serious complications such as ulcers and bleeding, which are potentially life-threatening conditions. Therefore, if a patient experiences symptoms suggestive of gastrointestinal bleeding—such as abdominal pain, black or bloody stools, or vomiting blood—Aspirin should be discontinued immediately to prevent further harm and to allow for appropriate medical intervention.

In contrast, while headache and diarrhea can be uncomfortable, they do not typically require stopping Aspirin, as they are not direct contraindications. Tinnitus, although it can occur with high doses of Aspirin, does not warrant immediate discontinuation unless it is severe or bothersome, and even then, it might not be necessary to stop Aspirin entirely. Gastric upset or mild side effects are monitored rather than leading to abrupt cessation unless there are specific, more serious related symptoms.