Which of the following cephalosporins should not be reconstituted with calcium-containing products?

Ceftriaxone should not be reconstituted with calcium-containing products due to the risk of precipitate formation, which can occur when ceftriaxone and calcium are administered together. This risk is particularly significant in neonates, where the combination can lead to serious complications such as respiratory distress and potentially fatal outcomes. Ceftriaxone can bind with calcium, resulting in the formation of unsafe precipitates that can cause significant harm.

In contrast, the other cephalosporins listed, such as cefepime, cefdinir, and cefixime, do not carry the same risk of adverse reactions when given alongside calcium-containing products. Therefore, it is crucial to avoid administering ceftriaxone with any calcium source, emphasizing the importance of understanding drug compatibility and interactions in clinical practice.