Which medication should be discontinued if gallstones are discovered?

Fenofibrate is the correct choice to discontinue if gallstones are discovered due to its association with biliary issues. Fenofibrate is a medication that helps lower cholesterol and triglycerides in the blood but can increase the risk of gallstone formation. When gallstones are present, this medication can exacerbate symptoms and lead to complications such as cholecystitis or pancreatitis.

In contrast, the other medications mentioned—Lovaza, Evkeeza, and Nexletol—do not have similar associations with gallstone complications. Lovaza is an omega-3 fatty acid that primarily affects triglyceride levels without a direct link to gallstone formation. Evkeeza, targeting specific lipid levels related to cardiovascular risk, and Nexletol, a newer medication for cholesterol management, also do not carry the same warnings regarding gallstones as fenofibrate does. Thus, it is safest to discontinue fenofibrate in a case where gallstones are identified.