Which medication requires administration via a weekly patch?

Clonidine is the medication that requires administration via a weekly patch. The transdermal patch allows for continuous delivery of clonidine through the skin, providing consistent therapeutic levels over the week. This method of administration is advantageous as it helps maintain stable plasma concentrations and improves patient compliance by reducing the frequency of dosing.

Clonidine acts as an alpha-2 adrenergic agonist, typically used for managing hypertension, ADHD, and certain pain conditions. The patch formulation can also help mitigate some side effects associated with oral forms of the medication, such as fluctuations in blood pressure.

In contrast, the other medications listed are not administered via a patch. Prazosin and alfuzosin are taken orally for managing hypertension and benign prostatic hyperplasia, respectively, while Flomax (tamsulosin) is specifically used for benign prostatic hyperplasia and is also administered orally. Therefore, clonidine is the unique choice that utilizes a weekly patch for effective delivery.