Which medication requires administration on an empty stomach?

The correct choice is Rybelsus, as it is specifically designed to be taken on an empty stomach to enhance its absorption and effectiveness. Rybelsus is an oral GLP-1 receptor agonist used for managing type 2 diabetes. When ingested without food, the gastrointestinal transit time is decreased, allowing for optimal absorption of the medication in the intestines.

Taking Rybelsus with food can significantly affect its absorption, leading to decreased efficacy in controlling blood glucose levels. For patients, this means that adherence to the instruction of taking it on an empty stomach—typically at least 30 minutes before the first meal of the day—is crucial for achieving the desired therapeutic outcomes.

In contrast, other medications listed, such as Trulicity, Wegovy, and Mounjaro, can be taken with or without food, which reflects their different pharmacokinetic profiles and mechanisms of action. Therefore, understanding the specific requirements for Rybelsus is essential for optimal patient care and medication management.