Which medication is necessary to help prevent mucositis when administering Methotrexate?

Leucovorin, also known as folinic acid, is a medication that plays a crucial role in preventing mucositis when administering Methotrexate. Methotrexate is a chemotherapy agent that can be toxic to rapidly dividing cells, such as those found in the mucosal lining of the mouth and gastrointestinal tract. This toxicity can lead to inflammation and ulceration, known as mucositis.

Leucovorin acts as a rescue therapy, effectively providing a source of folate that helps to mitigate the toxicity caused by Methotrexate. It quickly gets absorbed and can alleviate the harm to the normal healthy cells that Methotrexate affects, thereby reducing the risk and severity of mucositis. By administering Leucovorin in conjunction with Methotrexate, the body is supported to replenish folate levels and improve mucosal health, consequently helping to prevent the painful side effects associated with mucositis.

The other medications listed do not have this specific protective role against the mucosal toxicities associated with Methotrexate and are used in different clinical contexts. Understanding the role of Leucovorin in this setting allows for better management of chemotherapy side effects, enhancing patient comfort and treatment efficacy.