Which medication is indicated for both Bipolar disorder and Major Depressive Disorder (MDD)?

The medication indicated for both Bipolar Disorder and Major Depressive Disorder (MDD) is Symbyax. Symbyax is a combination medication that contains olanzapine, which is an atypical antipsychotic, and fluoxetine, a selective serotonin reuptake inhibitor (SSRI). This combination is specifically approved for the treatment of depressive episodes associated with Bipolar Disorder and for the treatment of Major Depressive Disorder in adults.

The use of Symbyax takes advantage of the different mechanisms of action of its components — olanzapine helps to stabilize mood and reduce psychotic symptoms, while fluoxetine addresses the depressive symptoms by increasing serotonin levels in the brain. This dual action makes Symbyax effective for individuals dealing with both bipolar disorder and major depression, which often co-occur.

In contrast, Haloperidol is primarily used for schizophrenia and acute psychosis but is not typically indicated for MDD. Abilify, while it is used to treat bipolar disorder and can augment antidepressant therapy, is not specifically indicated for MDD on its own. Perseris, which is a long-acting injectable formulation of risperidone, is also not indicated for MDD but is primarily used in the treatment of schizophrenia.