Which electrolyte imbalances can result from Amphotericin B use?

Amphotericin B is known to cause specific electrolyte imbalances, particularly resulting in decreased levels of potassium and magnesium in the body. This is attributed to the drug's mechanism of action, as it interacts with cell membranes and can lead to increased renal excretion of these electrolytes. Hypokalemia, or low potassium levels, can lead to various complications such as muscle weakness, arrhythmias, and other cardiovascular issues. Similarly, hypomagnesemia, or low magnesium levels, can also cause neuromuscular excitability and metabolic disturbances.

Given the known side effects of Amphotericin B, clinical monitoring for potassium and magnesium levels is essential during treatment to prevent these imbalances from causing significant health issues. This understanding is crucial for safely managing patients undergoing treatment with Amphotericin B and ensuring that necessary interventions are in place if electrolyte disturbances occur.