Which diuretic class works at the thick ascending loop of Henle?

The correct answer, which identifies that loop diuretics work at the thick ascending loop of Henle, is accurate because these diuretics specifically target the Na-K-2Cl symporter located in this section of the nephron. By inhibiting this transporter, loop diuretics significantly decrease the reabsorption of sodium, potassium, and chloride ions, resulting in increased excretion of water, sodium, potassium, and other electrolytes.

Loop diuretics, such as furosemide, bumetanide, and torsemide, are known for their potency and rapid onset of action. Their primary therapeutic use includes managing conditions like congestive heart failure, renal impairment, and edema, as well as controlling hypertension.

In contrast, thiazides primarily act on the distal convoluted tubule, potassium-sparing diuretics generally affect the late distal and collecting ducts, and carbonic anhydrase inhibitors, like acetazolamide, work in the proximal tubule. Thus, loop diuretics are uniquely positioned in their ability to affect the thick ascending limb of Henle, making them particularly effective in promoting diuresis.