Which class of medications is NOT associated with increasing Lithium levels?

Beta-blockers are not typically associated with increasing lithium levels. While each class of medication interacts with lithium differently, beta-blockers are primarily used to manage conditions such as hypertension and anxiety without affecting lithium metabolism significantly.

In contrast, non-steroidal anti-inflammatory drugs (NSAIDs), ACE inhibitors, and thiazide diuretics all have been documented to influence lithium levels. NSAIDs can reduce the renal clearance of lithium, leading to increased serum levels. ACE inhibitors can also affect renal function, potentially increasing lithium concentrations. Thiazide diuretics may cause dehydration or electrolyte imbalances, which can result in elevated lithium levels through decreased renal clearance or other mechanisms.

Understanding these interactions is vital for clinicians managing patients on lithium therapy, as certain medications can lead to toxicity if not monitored closely.