Which cephalosporin is often associated with a higher incidence of side effects compared to other beta-lactams?

Cefotetan is often associated with a higher incidence of side effects compared to other beta-lactams due to its unique chemical structure and specific side-chain characteristics. This cephalosporin, particularly in the second-generation category, is known to have increased potential for adverse reactions, including the disulfiram-like reaction. This reaction can occur when the patient consumes alcohol while on cefotetan, leading to flushing, palpitations, and other uncomfortable symptoms. Additionally, cefotetan can also interfere with certain laboratory tests, such as the measurement of prothrombin time, leading to bleeding complications due to its effect on vitamin K synthesis.

While other cephalosporins like cephalexin, cefepime, and cefdinir might cause side effects, they are generally not noted for having the pronounced adverse reactions associated with cefotetan. This distinction contributes to cefotetan's reputation for having a higher side-effect profile, underscoring the importance of monitoring patient reactions and educating about potential interactions with substances like alcohol during treatment.