Which beta-blocker is known for causing a positive ANA test due to lupus-like effects?

Acebutolol is recognized for its association with drug-induced lupus erythematosus, which can result in a positive antinuclear antibody (ANA) test. The incidence of lupus-like reactions with acebutolol is attributed to its structural similarities with procainamide, a medication known to cause similar effects. This immune response can manifest as symptoms such as joint pain and a positive ANA test, which is often used in diagnosing autoimmune conditions.

Other beta-blockers listed, like atenolol, bisoprolol, and esmolol, typically do not have a recognized association with inducing lupus-like symptoms or leading to positive ANA tests. Thus, acebutolol stands out in this context due to its specific profile.