Which ARB is associated with sprue-like enteropathy?

Olmesartan is the angiotensin II receptor blocker (ARB) that has been associated with sprue-like enteropathy, a condition that mimics celiac disease and is characterized by gastrointestinal symptoms such as chronic diarrhea, weight loss, and malabsorption. The mechanism by which olmesartan may lead to these symptoms appears to be related to its effect on the intestinal mucosa, potentially causing an autoimmune response that damages the villi in the intestines, leading to malabsorption issues similar to those found in sprue or gluten-sensitive enteropathy.

This association has been significant enough that warnings and recommendations have been issued related to the use of olmesartan, urging healthcare providers to monitor for symptoms of enteropathy in patients taking this medication. Understanding this link emphasizes the importance of recognizing adverse gastrointestinal effects as a potential side effect of olmesartan use, which helps in diagnosing and managing patients who may be experiencing these symptoms.