Which ACE inhibitor must be taken on an empty stomach?

Captopril is the ACE inhibitor that must be taken on an empty stomach because food can significantly affect its absorption. To achieve optimal plasma levels, it is recommended that captopril be taken at least one hour before meals or two hours after meals. This is crucial for ensuring the medication's effectiveness and minimizing variability in its therapeutic effects.

Other ACE inhibitors, such as moexipril, fosinopril, and enalaprilat, do not have strict requirements regarding food and can be taken with or without food, allowing for more flexibility in administration. Understanding this distinction is important for patient education and medication adherence, as it directly impacts the efficacy of the treatment regimen.