Which ACE inhibitor is known for requiring dosing three times daily?

Captopril is known for requiring dosing three times daily due to its relatively short half-life. This means that the medication is metabolized and eliminated from the body more quickly than some other ACE inhibitors, necessitating more frequent administration to maintain therapeutic levels and effectively control blood pressure.

The pharmacokinetics of captopril dictate its dosing schedule; as the drug is cleared from the bloodstream more rapidly, dividing the total daily dose into three smaller doses ensures consistent blood levels and improves the efficacy of the treatment. This is in contrast to other ACE inhibitors, which may have longer half-lives and can often be dosed once or twice daily, providing more flexibility for patients and their adherence to medication regimens.