What symptom is commonly associated with the administration of Adrucil (fluorouracil)?

Hand-foot syndrome is a well-documented adverse effect associated with the administration of Adrucil (fluorouracil). This syndrome, also referred to as palmar-plantar erythrodysesthesia, manifests as redness, swelling, and pain in the palms of the hands and soles of the feet. It can occur due to the toxic effects of fluorouracil on rapidly dividing cells in the skin. Patients experiencing this symptom may notice discomfort, peeling, and even blistering in the affected areas, which can significantly impact their quality of life.

The other symptoms listed, such as constipation, coughing, and weight gain, are not typically linked to the use of fluorouracil. While certain medications or other conditions can cause these symptoms, they do not have a direct connection to the adverse effects commonly seen with Adrucil treatment. Therefore, understanding the management and implications of hand-foot syndrome is essential for patients receiving fluorouracil, aiding in monitoring and supportive care during treatment.