What skin condition is a potential side effect of Warfarin?

Skin necrosis is a potential side effect of Warfarin therapy, particularly in individuals who have protein C or S deficiency or those who begin anticoagulation therapy with Warfarin while already being on anticoagulant therapy that prevents coagulation naturally. Warfarin works by inhibiting vitamin K-dependent clotting factors, which can lead to a temporary pro-coagulation state due to the depletion of proteins C and S, causing small blood clots in the micro vasculature of the skin. This can result in skin necrosis due to tissue ischemia and infarction.

Other conditions such as rashes, fungal infections, or psoriasis are not directly linked to Warfarin use. Rashes can occur for various reasons and are not specifically a consequence of the medication, while fungal infections and psoriasis are unrelated to anticoagulation therapy and have different underlying causes. Therefore, skin necrosis is distinct in being a serious and recognized side effect of Warfarin.