What serious side effect is associated with Valproic Acid, indicated by the letter "H" in its mnemonic?

Valproic Acid is known to have several potential side effects, of which hepatotoxicity is particularly serious. This side effect refers to liver damage that can occur as a result of the medication. Valproic Acid has been associated with hepatic failure, especially in certain populations such as children under two years of age, and those who are also receiving other medications that may affect liver function.

In clinical practice, it is crucial to monitor liver enzymes and assess liver function regularly when a patient is on Valproic Acid. The risk of hepatotoxicity underscores the importance of understanding the medication's profile, including the common mnemonic that highlights key adverse effects. Recognizing hepatotoxicity as one of the major risks associated with Valproic Acid helps healthcare providers ensure patient safety through appropriate monitoring and preventive measures.

The other options, while they may relate to Valproic Acid or other medications, do not align with the critical and serious side effect represented by the letter "H" in the mnemonic, making hepatotoxicity the most relevant and informative answer in this context.