What potential concern should be monitored when using Methyldopa in treatment?

When considering the use of Methyldopa in treatment, the potential concern that should be monitored is the risk of lupus. Methyldopa, which is an antihypertensive medication often used during pregnancy, has been associated with the development of drug-induced lupus erythematosus in some patients. This condition is characterized by symptoms such as joint pain, rash, and fatigue, similar to systemic lupus erythematosus, but generally resolves after discontinuation of the drug.

Vigilant monitoring for signs of this adverse reaction is crucial for ensuring patient safety, especially given Methyldopa's widespread use in populations that may already be at higher risk for autoimmune conditions. While other side effects like dry mouth, reflex tachycardia, and constipation can occur, the specific and noteworthy association of Methyldopa with lupus necessitates a particular focus on this potential adverse effect during treatment.