What must be monitored when a patient is on Clozapine?

Clozapine is an atypical antipsychotic that is particularly effective in treatment-resistant schizophrenia. However, it carries a significant risk of agranulocytosis, a severe reduction in white blood cells that can lead to increased susceptibility to infections. Therefore, when a patient is on Clozapine, it is crucial to monitor the absolute neutrophil count (ANC).

The guideline for ANC monitoring stipulates that the ANC should remain above 1500 cells/mm³ to ensure patient safety while they are receiving this medication. Maintaining this level allows healthcare providers to detect any potential drop in white blood cell counts early, thus preventing serious complications associated with low neutrophil levels.

Monitoring blood pressure, liver enzymes, and kidney function are important for patients on many medications, including some antipsychotics, but these parameters are not the primary concern for patients taking Clozapine. The main focus remains on the ANC because of the specific risk that Clozapine poses in relation to blood cell counts.