What must be ensured when administering Lopinavir/Ritonavir oral solution?

The correct choice emphasizes the importance of refrigeration to maintain the potency of Lopinavir/Ritonavir oral solution. This medication needs to be stored at cooler temperatures to preserve its effectiveness and ensure that it remains stable over time. Storing it at room temperature could lead to degradation of the active ingredients, potentially compromising treatment efficacy.

When it comes to the other options, while they might hold some relevance in medication administration, they do not reflect the critical requirement for the specific storage condition of Lopinavir/Ritonavir. It is crucial to adhere to the storage guidelines provided for this medication to ensure that patients receive the full therapeutic benefit they need for their treatment.