What might be a consequence of using potassium-sparing diuretics with digoxin?

Using potassium-sparing diuretics in conjunction with digoxin can lead to an increased risk of hyperkalemia, which is an elevated level of potassium in the blood. Potassium-sparing diuretics, such as spironolactone or eplerenone, function by preventing the excretion of potassium in the urine, thus helping to maintain higher potassium levels.

When a patient is on digoxin, maintaining appropriate potassium levels is crucial, as digoxin's effects on the heart are closely related to potassium levels. High potassium levels can interfere with digoxin's therapeutic effects and potentially lead to toxicity. Therefore, the combination of digoxin with potassium-sparing diuretics can increase the risk of hyperkalemia, which presents a clinical concern for those managing a patient's medications and electrolytes.

In contrast, other options refer to effects that are not typically associated with this combination, such as the risk of hypokalemia, lowered blood pressure, or increased diuretic effect, making them less relevant in this context.