What major adverse effect is notably tested for SNRIs?

SNRIs, or serotonin-norepinephrine reuptake inhibitors, are known to have a significant impact on both serotonin and norepinephrine levels in the brain. One of the major adverse effects associated with SNRIs is hypertension. This occurs because norepinephrine can lead to increased vascular resistance and heart rate, consequently raising blood pressure.

In clinical practice, monitoring blood pressure is important when a patient is on SNRIs, particularly at higher doses. Unlike some of the other potential side effects, which may not be as consistently prominent, hypertension stands out due to its possible long-term cardiovascular implications. Therefore, clinicians often emphasize the need to regularly check blood pressure in patients treated with these medications to manage any risk of hypertension effectively.