What is the standard dosing method for Gentamicin?

Gentamicin, an aminoglycoside antibiotic, is often dosed using a once-daily method, especially for certain infections. This method is based on the pharmacokinetics of the drug, which show that gentamicin has a significantly prolonged post-antibiotic effect. The once-daily dosing schedule allows for higher peak concentrations of the drug while minimizing the time the drug is present in the body to reduce toxicity, particularly nephrotoxicity and ototoxicity.

Research has shown that this dosing strategy can be as effective, if not more so, than traditional multiple daily dosing regimens for treating serious infections caused by Gram-negative bacilli. It also promotes patient adherence and convenience, as it simplifies the medication schedule. Because the once-daily dosing allows for a better balance between efficacy and safety, this method is preferred in many clinical scenarios.