What is the recommended route for administering Bicillin LA (Penicillin G benzathine)?

Bicillin LA, which is a formulation of penicillin G benzathine, is specifically recommended to be administered via intramuscular (IM) injection. The reason for this route is that Bicillin LA is designed to provide a prolonged release of the antibiotic into the bloodstream.

When administered intramuscularly, the drug is slowly absorbed into the body, which helps to maintain therapeutic levels over an extended period, making it effective for treating certain infections such as syphilis, streptococcal pharyngitis, and rheumatic fever prophylaxis. This sustained release is crucial in ensuring that effective drug concentrations are maintained without the need for frequent dosing.

Oral administration would not be effective for this formulation as it is not designed for that route, and the bioavailability may be far less predictable. Subcutaneous and intravenous (IV) routes are not recommended for this specific antibiotic due to the formulation characteristics and the desired pharmacokinetic profile that IM administration provides. Thus, the recommendation for intramuscular injection ensures optimal effectiveness and safety of Bicillin LA.