What is the recommended dosing schedule for Isosorbide dinitrate (Isordil)?

The recommended dosing schedule for Isosorbide dinitrate (Isordil) is twice to three times a day (BID to TID). This dosing regimen is designed to provide effective management of angina while minimizing the development of tolerance to the medication. Isosorbide dinitrate is a nitrate that works by dilating blood vessels to improve blood flow and reduce the workload on the heart.

Dosing it multiple times throughout the day allows for more consistent symptom control, especially since the therapeutic effects can wear off, and a gap in administration could lead to increased angina episodes. By spreading the doses throughout the day, patients can maintain a stable level of medication in their system.

Other dosing frequencies, such as once daily, would not provide continuous control throughout the day, which can lead to periods of inadequate coverage for angina symptoms. Similarly, dosing every four hours could result in complications related to tolerance but is not typically the recommended standard. Lastly, only taking the medication as needed may not provide adequate management for frequent angina episodes.