What is the recommended dosing schedule for meglitinides?

Meglitinides are a class of medications used to manage blood glucose levels in individuals with type 2 diabetes. The primary mechanism of action involves stimulating the pancreas to release insulin, particularly in response to meals.

The recommended dosing schedule is to take meglitinides 1 to 30 minutes before meals. This timing is crucial because it aligns the peak action of the medication with the immediate postprandial (after meal) increase in blood glucose levels. By administering the medication shortly before eating, it allows for optimal control over blood glucose spikes that occur due to carbohydrate intake in the meal.

This dosing strategy enhances the efficacy of the drug and helps in minimizing the risk of hypoglycemia, which can occur if the medication is taken too far in advance of food intake. Therefore, taking meglitinides within this specified time frame is essential for achieving the therapeutic goals in managing blood glucose levels effectively.